Varghese J, James J, Vaulont S, Mckie A, Jacob M. Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1870-1882. doi: 10.1016/j.bbagen.2018.05.022. Epub 2018 May 31. PMID: 29859963; PMCID: PMC6029669.

Varghese J, James JV, Sagi S, Chakraborty S, Sukumaran A, Ramakrishna B, Jacob M. Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. Br J Nutr. 2016 Jun;115(11):1978-86. doi: 10.1017/S0007114516001197. Epub 2016 Apr 15. PMID: 27080262.

Patel N, Varghese J, Masaratana P, Latunde-Dada GO, Jacob M, Simpson RJ, McKie AT. The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels. Br J Haematol. 2014 Feb;164(4):586-96. doi: 10.1111/bjh.12649. Epub 2013 Nov 16. PMID: 24236640; PMCID: PMC4232863.

Varghese J, Jacob M. Do medical students require education on issues related to plagiarism? Indian J Med Ethics. 2015 Apr-Jun;12(2):82-7. doi: 10.20529/IJME.2015.026. Epub 2014 Nov 25. PMID: 25671582.

Sukumaran A, Varghese J, Tamilselvan J, Jeyaseelan V, Mani T, Simpson RJ, McKie AT, Jacob M. Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: a time-course study. Br J Nutr. 2012 Dec 14;108(11):1994-2001. doi: 10.1017/S0007114512000189. Epub 2012 Feb 24. PMID: 22360813.

Nagappan AS, Varghese J, James JV, Jacob M. Indomethacin induces endoplasmic reticulum stress, but not apoptosis, in the rat kidney. Eur J Pharmacol. 2015 Aug 15;761:199-205. doi: 10.1016/j.ejphar.2015.04.044. Epub 2015 May 7. PMID: 25958182.

Varghese J, James J, Vaulont S, Mckie A, Jacob M. Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1870-1882. doi: 10.1016/j.bbagen.2018.05.022. Epub 2018 May 31. PMID: 29859963; PMCID: PMC6029669.

Varghese J, James JV, Sagi S, Chakraborty S, Sukumaran A, Ramakrishna B, Jacob M. Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. Br J Nutr. 2016 Jun;115(11):1978-86. doi: 10.1017/S0007114516001197. Epub 2016 Apr 15. PMID: 27080262.

Patel N, Varghese J, Masaratana P, Latunde-Dada GO, Jacob M, Simpson RJ, McKie AT. The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels. Br J Haematol. 2014 Feb;164(4):586-96. doi: 10.1111/bjh.12649. Epub 2013 Nov 16. PMID: 24236640; PMCID: PMC4232863.

Varghese J, Jacob M. Do medical students require education on issues related to plagiarism? Indian J Med Ethics. 2015 Apr-Jun;12(2):82-7. doi: 10.20529/IJME.2015.026. Epub 2014 Nov 25. PMID: 25671582.

Sukumaran A, Varghese J, Tamilselvan J, Jeyaseelan V, Mani T, Simpson RJ, McKie AT, Jacob M. Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: a time-course study. Br J Nutr. 2012 Dec 14;108(11):1994-2001. doi: 10.1017/S0007114512000189. Epub 2012 Feb 24. PMID: 22360813.

Nagappan AS, Varghese J, James JV, Jacob M. Indomethacin induces endoplasmic reticulum stress, but not apoptosis, in the rat kidney. Eur J Pharmacol. 2015 Aug 15;761:199-205. doi: 10.1016/j.ejphar.2015.04.044. Epub 2015 May 7. PMID: 25958182.

Varghese J, Faith M, Jacob M. Zinc prevents indomethacin-induced renal damage in rats by ameliorating oxidative stress and mitochondrial dysfunction. Eur J Pharmacol. 2009 Jul 1;614(1-3):114-21. doi: 10.1016/j.ejphar.2009.04.053. Epub 2009 May 13. PMID: 19445918.

Nagappan AS, Varghese J, Pranesh GT, Jeyaseelan V, Jacob M. Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage. Chem Biol Interact. 2014 Sep 25;221:77-87. doi: 10.1016/j.cbi.2014.07.014. Epub 2014 Aug 8. PMID: 25110317.

Varghese J, Faith M, Jacob M. Impact of e-resources on learning in biochemistry: first-year medical students' perceptions. BMC Med Educ. 2012 May 16;12:21. doi: 10.1186/1472-6920-12-21. PMID: 22510159; PMCID: PMC3353857.

James JV, Varghese J, Mckie AT, Vaulont S, Jacob M. Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice. Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118621. doi: 10.1016/j.bbamcr.2019.118621. Epub 2019 Dec 5. PMID: 31812496.

Varghese J, Varghese James J, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE, Jacob M. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2020 Mar;58:126442. doi: 10.1016/j.jtemb.2019.126442. Epub 2019 Nov 28. PMID: 31835128.

Varghese J, James JV, Anand R, Narayanasamy M, Rebekah G, Ramakrishna B, Nellickal AJ, Jacob M. Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet. J Nutr Biochem. 2020 Oct;84:108441. doi: 10.1016/j.jnutbio.2020.108441. Epub 2020 Jun 2. PMID: 32629238; PMCID: PMC7115812.

Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics. J Diabetes Complications. 2021 Sep;35(9):107977. doi: 10.1016/j.jdiacomp.2021.107977. Epub 2021 Jun 19. PMID: Venkatesan P, Varghese J, Arthi TS, James JV, Anura A, Prasad J, Jacob M. Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics. J Diabetes Complications. 2021 Sep;35(9):107977. doi: 10.1016/j.jdiacomp.2021.107977. Epub 2021 Jun 19. PMID: 34217587

James JV, Varghese J, John NM, Deschemin JC, Vaulont S, McKie AT, Jacob M. Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin. J Nutr Biochem. 2023 Jan;111:109175. doi: 10.1016/j.jnutbio.2022.109175. Epub 2022 Oct 9. PMID: 36223834.

Varghese J, Jacob M. Gift authorship: Look the gift horse in the mouth. Indian J Med Ethics. 2022 Jul-Sep;VII(3):196-202. doi: 10.20529/IJME.2022.028. Epub 2022 Apr 21. PMID: 35699293.

Varghese J, Peter M, Kamath MS. Oogenesis Arrest Prior to Birth: A Trade-off between Possible Evolutionary Advantages and Age-Related Oocyte Dysfunction? Fertility & Reproduction. 2021 Sep 28;3(03):55-7 Link

Venkatesan P, Ramasamy J, Vanitha S, Jacob M, Varghese J. Impaired pancreatic beta-cell function after a single dose of oral iron: A before-and-after (pre-post) study. J Hum Nutr Diet. 2023 Jun;36(3):1111-1120. doi: 10.1111/jhn.13074. Epub 2022 Sep 7. PMID: 36000222.

Ramasamy J, Jagadish C, Sukumaran A, Varghese J, Mani T, Joseph AJ, Simon EG, Jacob M. Low Serum Hepcidin Levels in Patients with Ulcerative Colitis - Implications for Treatment of Co-existent Iron-Deficiency Anemia. Inflammation. 2023 Dec;46(6):2209-2222. doi: 10.1007/s10753-023-01872-9. Epub 2023 Jul 24. Erratum in: Inflammation. 2023 Aug 11 PMID: 37486527