Sr.professor
Christian Medical College Vellore, Ida Scudder Road, Vellore – 632004, Tamil Nadu, India.
Chowdhury SD, Joseph AJ, Pulimood A, Eapen A, Abraham V, John J, Chacko A. A gastric submucosal mass. Gut. 2010 Mar;59(3):291, 347. doi: 10.1136/gut.2009.181974. PMID: 20207634.
Goel A, Dutta AK, Pulimood AB, Eapen A, Chacko A. Clinical profile and predictors of disease behavior and surgery in Indian patients with Crohn's disease. Indian J Gastroenterol. 2013 May;32(3):184-9. doi: 10.1007/s12664-012-0293-y. Epub 2013 Feb 16. PMID: 23417764.
Maiwall R, Goel A, Pulimood AB, Babji S, Sophia J, Prasad C, Balasubramanian KA, Ramakrishna B, Kurian S, Fletcher GJ, Abraham P, Kang G, Ramakrishna BS, Elias E, Eapen CE. Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014 Nov;33(6):517-23. doi: 10.1007/s12664-014-0501-z. Epub 2014 Sep 18. PMID: 25231910.
Eapen CE, Madesh M, Balasubramanian KA, Pulimood A, Mathan M, Ramakrishna BS. Mucosal mitochondrial function and antioxidant defences in patients with gastric carcinoma. Scand J Gastroenterol. 1998 Sep;33(9):975-81. doi: 10.1080/003655298750027010. PMID: 9759955.
Faith M, Eapen CE, Wilfred G, Ramachandran J, Jacob M. Serum biotinidase is a sensitive and specific biochemical marker of hepatic dysfunction: A preliminary report. Hepatol Res. 2007 Jan;37(1):13-7. doi: 10.1111/j.1872-034X.2007.00002.x. PMID: 17300694. Link
Varghese J, Varghese James J, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE, Jacob M. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2020 Mar;58:126442. doi: 10.1016/j.jtemb.2019.126442. Epub 2019 Nov 28. PMID: 31835128.
Chowdhury SD, Joseph AJ, Pulimood A, Eapen A, Abraham V, John J, Chacko A. A gastric submucosal mass. Gut. 2010 Mar;59(3):291, 347. doi: 10.1136/gut.2009.181974. PMID: 20207634.
Goel A, Dutta AK, Pulimood AB, Eapen A, Chacko A. Clinical profile and predictors of disease behavior and surgery in Indian patients with Crohn's disease. Indian J Gastroenterol. 2013 May;32(3):184-9. doi: 10.1007/s12664-012-0293-y. Epub 2013 Feb 16. PMID: 23417764.
Maiwall R, Goel A, Pulimood AB, Babji S, Sophia J, Prasad C, Balasubramanian KA, Ramakrishna B, Kurian S, Fletcher GJ, Abraham P, Kang G, Ramakrishna BS, Elias E, Eapen CE. Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014 Nov;33(6):517-23. doi: 10.1007/s12664-014-0501-z. Epub 2014 Sep 18. PMID: 25231910.
Eapen CE, Madesh M, Balasubramanian KA, Pulimood A, Mathan M, Ramakrishna BS. Mucosal mitochondrial function and antioxidant defences in patients with gastric carcinoma. Scand J Gastroenterol. 1998 Sep;33(9):975-81. doi: 10.1080/003655298750027010. PMID: 9759955.
Faith M, Eapen CE, Wilfred G, Ramachandran J, Jacob M. Serum biotinidase is a sensitive and specific biochemical marker of hepatic dysfunction: A preliminary report. Hepatol Res. 2007 Jan;37(1):13-7. doi: 10.1111/j.1872-034X.2007.00002.x. PMID: 17300694. Link
Varghese J, Varghese James J, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE, Jacob M. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2020 Mar;58:126442. doi: 10.1016/j.jtemb.2019.126442. Epub 2019 Nov 28. PMID: 31835128.
Goel A, Ramakrishna B, Zachariah U, Sajith KG, Burad DK, Kodiatte TA, Keshava SN, Balasubramanian KA, Elias E, Eapen CE. What makes non-cirrhotic portal hypertension a common disease in India? Analysis for environmental factors. Indian J Med Res. 2019 Apr;149(4):468-478. doi: 10.4103/ijmr.IJMR_1405_17. PMID: 31411170; PMCID: PMC6676844.
Goel A, Ramakrishna B, Job V, Zachariah U, Eapen CE. Vitamin B12 Deficiency in Patients With Unexplained Portal Hypertension Indicates Absence of Severe Liver Fibrosis. J Clin Gastroenterol. 2019 Mar;53(3):e126-e127. doi: 10.1097/MCG.0000000000000673. PMID: 30742603.
Kapoor N, Cherian KE, Sajith KG, Thomas M, Eapen CE, Thomas N, Paul TV. Renal Tubular Function, Bone Health and Body Composition in Wilson's Disease: A Cross-Sectional Study from India. Calcif Tissue Int. 2019 Nov;105(5):459-465. doi: 10.1007/s00223-019-00588-z. Epub 2019 Jul 17. PMID: 31317233. Link
Eidelberg A, Kirubakaran R, Nair SC, Eapen CE, Elias E, Goel A. Systematic review: role of elevated plasma von-Willebrand factor as predictor of mortality in patients with chronic liver disease. Eur J Gastroenterol Hepatol. 2019 Oct;31(10):1184-1191. doi: 10.1097/MEG.0000000000001491. PMID: 31498279.
Fletcher GJ, Eapen CE, Abraham P. Hepatitis B genotyping: The utility for the clinicians. Indian J Gastroenterol. 2020 Aug;39(4):315-320. doi: 10.1007/s12664-019-00995-y. PMID: 31617082.
Ahmed M, Keshava SN, Moses V, Chiramel GK, Mammen S, Eapen CE, Zachariah UG. Transjugular Intrahepatic Portosystemic Shunt Through the Strut of a Previously Placed Stent: Technical Feasibility and Long-Term Follow-Up Results. Cardiovasc Intervent Radiol. 2018 Nov;41(11):1794-1798. doi: 10.1007/s00270-018-2033-x. Epub 2018 Jul 16. PMID: 30014251.
Raghupathy V, Goel A, Thangaraj KR, Eapen CE, Balasubramanian KA, Regi A, Jose R, Benjamin SJ, Ramachandran A. Absence of G1528C mutation in long-chain 3-hydroxyacyl-CoA dehydrogenase in four Indian patients with pregnancy-related liver disease. Indian J Gastroenterol. 2014 Jul;33(4):387-9. doi: 10.1007/s12664-013-0408-0. PMID: 24105666.
Ramachandran J, Eapen CE, Kang G, Abraham P, Hubert DD, Kurian G, Hephzibah J, Mukhopadhya A, Chandy GM. Hepatitis E superinfection produces severe decompensation in patients with chronic liver disease. J Gastroenterol Hepatol. 2004 Feb;19(2):134-8. doi: 10.1111/j.1440-1746.2004.03188.x. PMID: 14731121. Link
Ramakrishna, Banumathi, M.D., M.A.M.S.; Eapen, C. E., M.D., D.M.; Kang, Gagandeep, M.D., Ph.D.; Kurian, George, M.D., D.M.; Chandy, George M., M.D., D.M. Familial Intrahepatic Cholestatic Cirrhosis With Positive Antimitochondrial Antibody, Journal of Clinical Gastroenterology: April 2000 - Volume 30 - Issue 3 - p 255-258 Link
Goel A, Madhu K, Zachariah U, Sajith KG, Ramachandran J, Ramakrishna B, Gibikote S, Jude J, Chandy GM, Elias E, Eapen CE. A study of aetiology of portal hypertension in adults (including the elderly) at a tertiary centre in southern India. Indian J Med Res. 2013 May;137(5):922-7. PMID: 23760378; PMCID: PMC3734684.
Raman T, Mukhopadhyaya A, Eapen CE, Aruldas V, Bose A, Sen S, Estes MK, Kang G. Intussusception in southern Indian children: lack of association with diarrheal disease and oral polio vaccine immunization. Indian J Gastroenterol. 2003 May-Jun;22(3):82-4. PMID: 12839377.
Bera C, Michael JS, Burad D, Shirly SB, Gibikote S, Ramakrishna B, Goel A, Eapen CE. Tissue Xpert™ MTB/Rif assay is of limited use in diagnosing peritoneal tuberculosis in patients with exudative ascites. Indian J Gastroenterol. 2015 Sep;34(5):395-8. doi: 10.1007/s12664-015-0599-7. Epub 2015 Nov 4. PMID: 26531065.
Mammen T, Keshava SN, Eapen CE, Raghuram L, Moses V, Gopi K, Babu NS, Ramachandran J, Kurien G. Transjugular liver biopsy: a retrospective analysis of 601 cases. J Vasc Interv Radiol. 2008 Mar;19(3):351-8. doi: 10.1016/j.jvir.2007.09.002. PMID: 18295693. Link
Eapen CE, Mammen T, Moses V, Shyamkumar NK. Changing profile of Budd Chiari syndrome in India. Indian J Gastroenterol. 2007 Mar-Apr;26(2):77-81. PMID: 17558071. Link
Eapen, C. E. and Kandasamy, S. Improving outcomes with pharmacotherapy to treat acute esophageal variceal bleeding Indian J Gastroenterol; 2018, 37 (4): 279-280 Link
Goel A, Ramakrishna B, Muliyil J, Madhu K, Sajith KG, Zachariah U, Ramachandran J, Keshava SN, Selvakumar R, Chandy GM, Elias E, Eapen CE. Use of serum vitamin B12 level as a marker to differentiate idiopathic noncirrhotic intrahepatic portal hypertension from cryptogenic cirrhosis. Dig Dis Sci. 2013 Jan;58(1):179-87. doi: 10.1007/s10620-012-2361-7. Epub 2012 Aug 24. PMID: 22918688. Link
Pal S, Ramachandran J, Kurien RT, Eapen A, Ramakrishna B, Keshava SN, Goel A, Sajith KG, Eapen CE. Hepatocellular carcinoma continues to be diagnosed in the advanced stage: profile of hepatocellular carcinoma in a tertiary care hospital in South India. Trop Doct. 2013 Jan;43(1):25-6. doi: 10.1177/0049475512473600. Epub 2013 Feb 26. PMID: 23443626. Link
Livingstone RS, Grunnet LG, Thomas N, Eapen A, Antonisamy B, Mohan VR, Spurgeon R, Frank ID, Bygbjerg IC, Vaag A. Are hepatic and soleus lipid content, assessed by magnetic resonance spectroscopy, associated with low birth weight or insulin resistance in a rural Indian population of healthy young men? Diabet Med. 2016 Mar;33(3):365-70. doi: 10.1111/dme.12852. Epub 2015 Aug 18. PMID: 26172248. Link
Madhu K, Avinash B, Ramakrishna B, Eapen CE, Shyamkumar NK, Zachariah U, Chandy G, Kurian G. Idiopathic non-cirrhotic intrahepatic portal hypertension: common cause of cryptogenic intrahepatic portal hypertension in a Southern Indian tertiary hospital. Indian J Gastroenterol. 2009 May-Jun;28(3):83-7. doi: 10.1007/s12664-009-0030-3. Epub 2009 Nov 12. PMID: 19907954.
Sarawagi R, Keshava SN, Surendrababu NR, Zachariah UG, Eapen EC. Budd-Chiari syndrome complicating hydatid cyst of the liver managed by venoplasty and stenting. Cardiovasc Intervent Radiol. 2011 Feb;34 Suppl 2:S202-5. doi: 10.1007/s00270-010-9833-y. Epub 2010 Mar 24. PMID: 20333383.
Mammen T, Keshava S, Eapen CE, Moses V, Babu NR, Kurien G, Chandy G. Intrahepatic collateral recanalization in symptomatic Budd-Chiari syndrome: a single-center experience. J Vasc Interv Radiol. 2010 Jul;21(7):1119-24. doi: 10.1016/j.jvir.2010.03.008. Epub 2010 May 26. PMID: 20537910. Link
Surendrababu NR, Keshava SN, Eapen CE, Zachariah UG. Transjugular intrahepatic portocaval shunt placed through the strut of an inferior vena cava stent in a patient with Budd-Chiari syndrome: a technical modification. Br J Radiol. 2010 Jan;83(985):e22-4. doi: 10.1259/bjr/60833972. PMID: 20139245; PMCID: PMC3487257. Link
Eapen, C. E., Ramakrishna, B., & Balasubramanian, K. A. (2018) Analyzing lipids in the liver & in the red blood cell membrane in liver diseases. Indian journal of medical research, 147(4), 334–336. https://doi.org/10.4103/ijmr.IJMR_1770_17
Chelliah ST, Keshava SN, Moses V, Surendrababu NR, Zachariah UG, Eapen C. Measurement of hepatic venous pressure gradient revisited: Catheter wedge vs balloon wedge techniques. Indian J Radiol Imaging. 2011 Oct;21(4):291-3. doi: 10.4103/0971-3026.90693. PMID: 22223943; PMCID: PMC3249946.
Goel A, Ramakrishna B, Madhu K, Zachariah U, Ramachandran J, Keshava SN, Elias E, Eapen CE. Idiopathic noncirrhotic intrahepatic portal hypertension is an ongoing problem in India. Hepatology. 2011 Dec;54(6):2274; author reply 2274-5. doi: 10.1002/hep.24750. PMID: 22030741. Link
Goel A, Alagammai PL, Nair SC, Mackie I, Ramakrishna B, Muliyil J, Keshava SN, Eapen CE, Elias E. ADAMTS13 deficiency, despite well-compensated liver functions in patients with noncirrhotic portal hypertension. Indian J Gastroenterol. 2014 Jul;33(4):355-63. doi: 10.1007/s12664-014-0460-4. Epub 2014 Apr 24. PMID: 24756423.
Moses V, Keshava SN, Mammen S, Ahmed M, Eapen CE, Ramakrishna B. Trans-caval trans-jugular liver biopsy--a technical modification of trans-jugular liver biopsy. Br J Radiol. 2014 Nov;87(1043):20140327. doi: 10.1259/bjr.20140327. Epub 2014 Sep 24. PMID: 25248931; PMCID: PMC4207161. Link
Goel A, Christudoss P, George R, Ramakrishna B, Amirtharaj GJ, Keshava SN, Ramachandran A, Balasubramanian KA, Mackie I, Fleming JJ, Elias E, Eapen CE. Arsenicosis, possibly from contaminated groundwater, associated with noncirrhotic intrahepatic portal hypertension. Indian J Gastroenterol. 2016 May;35(3):207-15. doi: 10.1007/s12664-016-0660-1. Epub 2016 May 26. PMID: 27225799. Link
Gupta P, Choksi M, Goel A, Zachariah U, Sajith KG, Ramachandran J, Chandy G, Kurian G, Rebekah G, Eapen CE. Maintenance zinc therapy after initial penicillamine chelation to treat symptomatic hepatic Wilson's disease in resource constrained setting. Indian J Gastroenterol. 2018 Jan;37(1):31-38. doi: 10.1007/s12664-018-0829-x. Epub 2018 Feb 19. PMID: 29457214.
Lim SG, Phyo WW, Shah SR, Win KM, Hamid S, Piratvisuth T, Tan SS, Dan YY, Lee YM, Ahmed T, Yang WL, Chen KP, Kamat M, Wadhawan M, Madan K, Mehta R, Shukla A, Dhore P, Eapen CE, Abraham P, Tyagi S, Koshy A, Bwa AH, Jafri W, Abid S, Arisar FAQ, Tanwandee T, Yin TP, Tee HP, Hj Md Said RB, Goh KL, Ho SH, Mohamed R, Abu Bakar N. Findings from a large Asian chronic hepatitis C real-life study. J Viral Hepat. 2018 Dec;25(12):1533-1542. doi: 10.1111/jvh.12989. Epub 2018 Sep 27. PMI Link
Thomas VV, Kumar SE, Alexander V, Nadaraj A, Vijayalekshmi B, Prabhu S, Kumar S, Murugabharathy K, Thomas SM, Hansdak S, Carey R, Iyyadurai R, Pichamuthu K, Abhilash KPP, Varghese GM, Nair S, Goel A, Jeyaseelan L, Zachariah U, Zachariah A, Eapen CE. Plasma Von Willebrand Factor Levels Predict Survival in COVID-19 Patients Across the Entire Spectrum of Disease Severity. Indian J Hematol Blood Transfus. 2021 Jun 20:1-8. doi: 10.1007/s12288-021-01459-0. Epub ahead of print. PMID: 34177141; PMCID: PMC8214842.
Choudhury A, Kumar M, Sharma BC, Maiwall R, Pamecha V, Moreau R, Chawla YK, Duseja A, Mahtab M, Rahman S, Hamid SS, Butt AS, Jafri W, Tan SS, Devarbhavi H, Amarapurkar D, Ning Q, Eapen CE, Goel A, Kim DJ, Ghazinyan H, Shiha G, Lee GH, Abbas Z, Payawal DA, Dokmeci AK, Yuen MF, Lesmana LA, Sood A, Chan A, Lau GK, Jia JD, Duan Z, Yu C, Yokosuka O, Jain P, Bhadoria AS, Kumar G, Sarin SK; APASL ACLF working party. Systemic inflammatory response syndrome in acute-on-chronic liver failure: Relevance of 'golden window': A prospective study. J Gastroenterol Hepatol. 2017 Dec;32(12):1989-1997. doi: 10.1111/jgh.13799. PMID: 28374414.
Vivek R, Zachariah UG, Ramachandran J, Eapen CE, Rajan DP, Kang G. Characterization of hepatitis E virus from sporadic hepatitis cases and sewage samples from Vellore, south India. Trans R Soc Trop Med Hyg. 2013 Jun;107(6):363-7. doi: 10.1093/trstmh/trt030. PMID: 23677583; PMCID: PMC5454524.
David D, Raghavendran A, Goel A, Bharath Kumar C, Kodiatte TA, Burad D, Abraham P, Ramakrishna B, Joseph P, Ramachandran J, Eapen CE. Risk factors for non-alcoholic fatty liver disease are common in patients with non-B non-C hepatocellular carcinoma in India. Indian J Gastroenterol. 2017 Sep;36(5):373-379. doi: 10.1007/s12664-017-0785-x. Epub 2017 Oct 4. PMID: 28975595.
Maiwall R, Goel A, Pulimood AB, Babji S, Sophia J, Prasad C, Balasubramanian KA, Ramakrishna B, Kurian S, Fletcher GJ, Abraham P, Kang G, Ramakrishna BS, Elias E, Eapen CE. Investigation into celiac disease in Indian patients with portal hypertension. Indian J Gastroenterol. 2014 Nov;33(6):517-23. doi: 10.1007/s12664-014-0501-z. Epub 2014 Sep 18. PMID: 25231910. Link
Baiges A, Turon F, Simón-Talero M, Tasayco S, Bueno J, Zekrini K, Plessier A, Franchi-Abella S, Guerin F, Mukund A, Eapen CE, Goel A, Shyamkumar NK, Coenen S, De Gottardi A, Majumdar A, Onali S, Shukla A, Carrilho FJ, Nacif L, Primignani M, Tosetti G, La Mura V, Nevens F, Witters P, Tripathi D, Tellez L, Martínez J, Álvarez-Navascués C, Fraile López ML, Procopet B, Piscaglia F, de Koning B, Llop E, Romero-Cristobal M, Tjwa E, Monescillo-Francia A, Senzolo M, Perez-LaFuente M, Segarra A, Sarin SK, Hernández-Gea V, Patch D, Laleman W, Hartog H, Valla D, Genescà J, García-Pagán JC; REHEVASC, VALDIG an EASL consortium, Abernethy group. Congenital Extrahepatic Portosystemic Shunts (Abernethy Malformation): An International Observational Study. Hepatology. 2020 Feb;71(2):658-669. doi: 10.1002/hep.30817. Epub 2019 Aug 19. PMID: 31211875.
Bera C, Thangaraj K, Pati PK, Ramachandran J, Balasubramanian KA, Ramachandran A, Zachariah U, Sajith KG, Goel A, Eapen CE. Raised plasma levels of H2S and nitrate predict intrapulmonary vascular dilations: A preliminary report in patients with cryptogenic cirrhosis. Indian J Gastroenterol. 2018 May;37(3):209-214. doi: 10.1007/s12664-018-0862-9. Epub 2018 Jul 9. PMID: 29984390. Link
Eapen CE, Shyamkumar NK, Gibikote SV, Korah IP, Nair A, Samal SC, Chandy G. Images of interest. Hepatobiliary and pancreatic: man with recurrent jaundice and abdominal pain. J Gastroenterol Hepatol. 2000 Apr;15(4):454-55; discussion 456. doi: 10.1046/j.1440-1746.2000.2181a.x. PMID: 10824893. Link
Eapen CE, Nair SC. Potential danger of isolated platelet transfusion in patients with dengue infection. Indian J Med Res. 2017 Feb;145(2):158-160. doi: 10.4103/ijmr.IJMR_937_16. PMID: 28639589; PMCID: PMC5501045.
Kapoor N, Cherian KE, Sajith KG, Thomas M, Eapen CE, Thomas N, Paul TV. Renal Tubular Function, Bone Health and Body Composition in Wilson's Disease: A Cross-Sectional Study from India. Calcif Tissue Int. 2019 Nov;105(5):459-465. doi: 10.1007/s00223-019-00588-z. Epub 2019 Jul 17. PMID: 31317233.
Sajith KG, Kapoor N, Shetty S, Goel A, Zachariah U, Eapen CE, Paul TV. Bone Health and Impact of Tenofovir Treatment in Men with Hepatitis-B Related Chronic Liver Disease. J Clin Exp Hepatol. 2018 Mar;8(1):23-27. doi: 10.1016/j.jceh.2017.05.009. Epub 2017 May 15. PMID: 29743793; PMCID: PMC5938523.
Nagral A, Sarma MS, Matthai J, Kukkle PL, Devarbhavi H, Sinha S, Alam S, Bavdekar A, Dhiman RK, Eapen CE, Goyal V, Mohan N, Kandadai RM, Sathiyasekaran M, Poddar U, Sibal A, Sankaranarayanan S, Srivastava A, Thapa BR, Wadia PM, Yachha SK, Dhawan A. Wilson's Disease: Clinical Practice Guidelines of the Indian National Association for Study of the Liver, the Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition, and the Movement Disorders Society of India. J Clin Exp Hepatol. 2019 Jan-Feb;9(1):74-98. doi: 10.1016/j.jceh.2018.08.009. Epub 2018 Sep 3. Erratum in: J Clin Exp Hepatol. 2020 Jan-Feb;10(1):99. PMID: 30765941; PMCID: PMC6363961.
Loganathan G, Shyamkumar NK, Kurian G, Eapen CE, Korah IP, Gnanaraj L, Chandy GM. Vesical varix in cirrhosis of liver. Indian J Gastroenterol. 2000 Oct-Dec;19(4):193-4. PMID: 11059194.
Goel A, Raghupathy V, Amirtharaj GJ, Chapla A, Venkatraman A, Ramakrishna B, Ramachandran A, Thomas N, Balasubramanian KA, Mackie I, Elias E, Eapen CE. ADAMTS13 missense variants associated with defective activity and secretion of ADAMTS13 in a patient with non-cirrhotic portal hypertension. Indian J Gastroenterol. 2017 Sep;36(5):380-389. doi: 10.1007/s12664-017-0786-9. Epub 2017 Oct 5. PMID: 28980147.
Eapen CE, Elias JE, Mackie I, Elias E. Prognostic significance of von willebrand factor in cirrhosis: a possible mechanism. Hepatology. 2013 Sep;58(3):1189. doi: 10.1002/hep.26282. Epub 2013 Jul 29. PMID: 23348722.
Elias JE, Mackie I, Eapen CE, Chu P, Shaw JC, Elias E. Porto-pulmonary hypertension exacerbated by platelet transfusion in a patient with ADAMTS13 deficiency. J Hepatol. 2013 Apr;58(4):827-30. doi: 10.1016/j.jhep.2012.11.003. Epub 2012 Nov 10. PMID: 23149063.
Goel A, Eapen CE, Danda D. Infliximab and occult hepatitis B infection: to treat or not to treat? J Rheum Dis. 2013 Aug;16(4):377-8. doi: 10.1111/1756-185X.12184. PMID: 23992254.
Ismail AM, Sharma OP, Kumar MS, Eapen CE, Kannangai R, Abraham P. Virological response and antiviral resistance mutations in chronic hepatitis B subjects experiencing entecavir therapy: an Indian subcontinent perspective. Antiviral Res. 2013 May;98(2):209-16. doi: 10.1016/j.antiviral.2013.02.012. Epub 2013 Feb 26. PMID: 23485939. Link
Choudhury A, Vijayaraghavan R, Maiwall R, Kumar M, Duan Z, Yu C, Hamid SS, Jafri W, Butt AS, Devarbhavi H, Ning Q, Ma K, Tan SS, Shukla A, Dhiman R, Duseja A, Taneja S, Eapen CE, Goel A, Treeprasertsuk S, Al-Mahtab M, Ghazinyan H, Kim DJ, Sahu MK, Lee GH, Lesmana LA, Lesmana RC, Shah S, Abbas Z, Sollano JD, Rao PN, Kulkarni A, Shiha G, Shrestha A, Dokmeci A, Yuen MF, Payawal DA, Kalista KF, Prasad VGM, Lau GK, Karim F, Jain P, Kumar G, Arora V, Pamecha V, Sinha P, Sarin SK; APASL ACLF Research Consortium (AARC) for APASL ACLF Working Party. 'First week' is the crucial period for deciding living donor liver transplantation in patients with acute-on-chronic liver failure. Hepatol Int. 2021 Dec;15(6):1376-1388. doi: 10.1007/s12072-021-10206-6. Epub 2021 Oct 4. PMID: 34608586.
Sharma A, Keshava SN, Eapen A, Elias E, Eapen CE. An Update on the Management of Budd-Chiari Syndrome. Dig Dis Sci. 2021 Jun;66(6):1780-1790. doi: 10.1007/s10620-020-06485-y. Epub 2020 Jul 20. PMID: 32691382. Link
Mukherjee PS, Vishnubhatla S, Amarapurkar DN, Das K, Sood A, Chawla YK, Eapen CE, Boddu P, Thomas V, Varshney S, Hidangmayum DS, Bhaumik P, Thakur B, Acharya SK, Chowdhury A. Etiology and mode of presentation of chronic liver diseases in India: A multi centric study. PLoS One. 2017 Oct 26;12(10):e0187033. doi: 10.1371/journal.pone.0187033. PMID: 29073197; PMCID: PMC5658106.
Goel A, Zachariah U, Ramakrishna B, Elias E, Eapen CE. Baveno-VI clinical staging of cirrhosis under-estimates 5-year survival after variceal bleed in cryptogenic chronic liver disease patients in India. Eur J Gastroenterol Hepatol. 2021 Sep 1;33(9):1232-1234. doi: 10.1097/MEG.0000000000002227. PMID: 34397643.
Anand AC, Nandi B, Acharya SK, Arora A, Babu S, Batra Y, Chawla YK, Chowdhury A, Chaoudhuri A, Eapen EC, Devarbhavi H, Dhiman RK, Datta Gupta S, Duseja A, Jothimani D, Kapoor D, Kar P, Khuroo MS, Kumar A, Madan K, Mallick B, Maiwall R, Mohan N, Nagral A, Nath P, Panigrahi SC, Pawar A, Philips CA, Prahraj D, Puri P, Rastogi A, Saraswat VA, Saigal S, Shalimar, Shukla A, Singh SP, Verghese T, Wadhawan M; INASL Task-Force on Acute Liver Failure. Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure . J Clin Exp Hepatol. 2020 Sep-Oct;10(5):477-517. doi: 10.1016/j.jceh.2020.04.011. Epub 2020 Apr 22. PMID: 33029057; PMCID: PMC7527855. Link
Burad DK, Kodiatte TA, Rajeeb SM, Goel A, Eapen CE, Ramakrishna B. Neuroendocrine neoplasms of liver - A 5-year retrospective clinico-pathological study applying World Health Organization 2010 classification. World J Gastroenterol. 2016 Oct 28;22(40):8956-8966. doi: 10.3748/wjg.v22.i40.8956. PMID: 27833387; PMCID: PMC5083801.
David D, Raghavendran A, Goel A, Bharath Kumar C, Kodiatte TA, Burad D, Abraham P, Ramakrishna B, Joseph P, Ramachandran J, Eapen CE. Risk factors for non-alcoholic fatty liver disease are common in patients with non-B non-C hepatocellular carcinoma in India. Indian J Gastroenterol. 2017 Sep;36(5):373-379. doi: 10.1007/s12664-017-0785-x. Epub 2017 Oct 4. PMID: 28975595. Link
Zachariah U, Goel A, Balasubramanian KA, Eapen CE. The Hibernating Bear-A Good Analogy to Explain Why Acute Fatty Liver of Pregnancy Manifests in Late Pregnancy. Am J Gastroenterol. 2018 Feb;113(2):307-308. doi: 10.1038/ajg.2017.462. PMID: 29467534. Link
Jaleel R, Sharma A, Selvaraj V, Aaron R, Muliyil J, Vijayalekshmi B, Dynamic scoring of appetite predicts inpatient survival in patients with acute‑on‑chronic liver failure. Gastroenterol Hepatol Endosc Pract 2021;1:143-7. DOI:10.4103/ghep.ghep_8_21
Eapen CE, Elias E, Goel A, John TJ. Hypothesis of mechanism of thrombocytopenia in severe dengue, providing clues to better therapy to save lives. Current Science ;2015, January:8(2) :168-169.
John TJ, Eapen CE. Atypical features of severe dengue: probable pathogenesis. Indian Pediatr. 2015 Apr;52(4):350-1. PMID: 25929648.
Puri P, Dhiman RK, Taneja S, Tandon P, Merli M, Anand AC, Arora A, Acharya SK, Benjamin J, Chawla YK, Dadhich S, Duseja A, Eapan CE, Goel A, Kalra N, Kapoor D, Kumar A, Madan K, Nagral A, Pandey G, Rao PN, Saigal S, Saraf N, Saraswat VA, Saraya A, Sarin SK, Sharma P, Shalimar, Shukla A, Sidhu SS, Singh N, Singh SP, Srivastava A, Wadhawan M. Nutrition in Chronic Liver Disease: Consensus Statement of the Indian National Association for Study of the Liver. J Clin Exp Hepatol. 2021 Jan-Feb;11(1):97-143. doi: 10.1016/j.jceh.2020.09.003. Epub 2020 Oct 1. PMID: 33679050; PMCID: PMC7897902.
Simon EG, Joseph AJ, George B, Zachariah UG, Jeyamani R, Eapen CE, Chandy G, Ramakrishna BS, Kurian G, Chacko A. Aetiology of paediatric portal hypertension - experience of a tertiary care centre in South India. Trop Doct. 2009 Jan;39(1):42-4. doi: 10.1258/td.2008.080050. PMID: 19211426. Link
David D, Eapen CE. What Are the Current Pharmacological Therapies for Nonalcoholic Fatty Liver Disease? J Clin Exp Hepatol. 2021 Mar-Apr;11(2):232-238. doi: 10.1016/j.jceh.2020.09.001. Epub 2020 Sep 3. PMID: 33746449; PMCID: PMC7953000.
Goel R, Eapen CE. Recognizing dysfunctional innate and adaptive immune responses contributing to liver damage in patients with cirrhosis. J Clin Exp Hepatol. 2021 Oct 14. doi: 10.1016/j.jceh.2021.10.001. Epub ahead of print. PMID: 34744379; PMCID: PMC8560502.
Keshava SN, Moses V, Sharma A, Ahmed M, Narayanan S, Padmanabhan A, Goel A, Zachariah U, Eapen CE. Technical and Medium-Term Clinical Outcomes of Transjugular Intrahepatic Portosystemic Shunt with Fluoroscopy and Additional Trans-abdominal Ultrasound Guidance. Indian J Radiol Imaging. 2021 Nov 30;31(4):858-866. doi: 10.1055/s-0041-1735928. PMID: 35136497; PMCID: PMC8817814.
Anand AC, Nandi B, Acharya SK, Anil Arora A, Babu S, Batra Y, Chawla YK, Chowdhury A, Chaoudhuri A, Eapen CE, Devarbhavi H, Dhiman RK, Datta S, Gupta , Duseja A, Jothimani D, Kapoor D, Kar P, Khuroo MS, Kumar A, Madan K, Mallick B, Maiwall R, Mohan N, Nagral A, Nath P, Panigrahi SC, Pawar A, Philips CA, Prahraj D, Puri P, 25,Rastogi A, Saraswat VA, Saigal S,Shalimar , Shukla A,Singh SP, Verghese T, Wadhawan M, INASL Task-Force on Acute Liver Failure. Erratum to 'Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure' [J Clin Exp Hepatol 10 (2020) 477-517]. J Clin Exp Hepatol Mar-Apr 2022;12(2):729-730. doi: 10.1016/j.jceh.2022.01.003, PMID: 35535113 PMCID: PMC9077233.
Thomas RJ, Fletcher GJ, Kirupakaran H, Chacko MP, Thenmozhi S, Eapen CE, Chandy G, Abraham P. Prevalence of non-responsiveness to an indigenous recombinant hepatitis B vaccine: a study among South Indian health care workers in a tertiary hospital. Indian J Med Microbiol. 2015 Feb;33 Suppl:32-6. doi: 10.4103/0255-0857.150877. PMID: 25657153.
Koshy CG, Eapen CE, Lakshminarayan R. Transvenous embolization to treat uncontrolled hemobilia and peritoneal bleeding after transjugular liver biopsy. Cardiovasc Intervent Radiol. 2010 Jun;33(3):624-6. doi: 10.1007/s00270-009-9610-y. Epub 2009 May 30. PMID: 19484288.
Eapen CE, Venkataraman J. Rodenticide (Yellow Phosphorus Poison)-Induced Hepatotoxicity in India: Constraints During Management. J Clin Exp Hepatol. 2021 Jul-Aug;11(4):414-417. doi: 10.1016/j.jceh.2021.04.011. Epub 2021 Apr 30. PMID: 34276149; PMCID: PMC8267345. Link
Goel A, Nair SC, Viswabandya A, Masilamani VP, Rao SV, George A, Regi A, Jose R, Zachariah U, Subramani K, Eapen CE, Chandy G. Preliminary experience with use of recombinant activated factor VII to control postpartum hemorrhage in acute fatty liver of pregnancy and other pregnancy-related liver disorders. Indian J Gastroenterol. 2013 Jul;32(4):268-71. doi: 10.1007/s12664-013-0315-4. Epub 2013 Mar 10. PMID: 23475547.
Anand AC, Nandi B, Acharya SK, Arora A, Babu S, Batra Y, Chawla YK, Chowdhury A, Chaoudhuri A, Eapen EC, Devarbhavi H, Dhiman RK, Datta Gupta S, Duseja A, Jothimani D, Kapoor D, Kar P, Khuroo MS, Kumar A, Madan K, Mallick B, Maiwall R, Mohan N, Nagral A, Nath P, Panigrahi SC, Pawar A, Philips CA, Prahraj D, Puri P, Rastogi A, Saraswat VA, Saigal S, Shalimar, Shukla A, Singh SP, Verghese T, Wadhawan M; INASL Task-Force on Acute Liver Failure. Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure. J Clin Exp Hepatol. 2020 Sep-Oct;10(5):477-517. doi: 10.1016/j.jceh.2020.04.011. Epub 2020 Apr 22. Erratum in: J Clin Exp Hepatol. 2022 Mar-Apr;12(2):729-730. PMID: 33029057; PMCID: PMC7527855.
Jacob SE, Shankar R, John A, Eapen CE, Yadav B, Rathore S. Maternal and neonatal outcomes in extra hepatic portal vein obstruction: Our experience. J Family Med Prim Care. 2021 Jul;10(7):2608-2613. doi: 10.4103/jfmpc.jfmpc_1486_20. Epub 2021 Jul 30. PMID: 34568143; PMCID: PMC8415649. Link
Anand AC, Nandi B, Acharya SK, Arora A, Babu S, Batra Y, Chawla YK, Chowdhury A, Chaoudhuri A, Eapen EC, Devarbhavi H, Dhiman R, Datta Gupta S, Duseja A, Jothimani D, Kapoor D, Kar P, Khuroo MS, Kumar A, Madan K, Mallick B, Maiwall R, Mohan N, Nagral A, Nath P, Panigrahi SC, Pawar A, Philips CA, Prahraj D, Puri P, Rastogi A, Saraswat VA, Saigal S, Shalimar, Shukla A, Singh SP, Verghese T, Wadhawan M; INASL Task-Force on Acute Liver Failure. Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis. J Clin Exp Hepatol. 2020 Jul-Aug;10(4):339-376. doi: 10.1016/j.jceh.2020.04.012. Epub 2020 Apr 28. PMID: 32655238; PMCID: PMC7335721
Thakur P, Cherian KE, Kapoor N, Rebekah G, Goel A, Zachariah U, Eapen CE, Thomas N, Paul TV. Proximal Hip Geometry, Trabecular Bone Score, Bone Mineral Density and Bone Mineral Parameters in Patients With Cryptogenic and Hepatitis B Related Cirrhosis- A Study From the Indian Subcontinent. J Clin Densitom. 2022 Jan-Mar;25(1):97-104. doi: 10.1016/j.jocd.2021.03.001. Epub 2021 Mar 4. PMID: 33789805.
Sajith KG, Goel A, Ramachandran J, Priya S, Nair SC, Eapen CE. Erythrocytosis as a cause of false increase in prothrombin time and activated partial thromboplastin time. Indian J Gastroenterol. 2013 Sep;32(5):346-7. doi: 10.1007/s12664-012-0277-y. PMID: 23114799.
Gnanadeepam S, Janeela AM, Zachariah U, Eapen CE, Goel A. Sarcopenia is Closely Associated With Frailty in Decompensated Cirrhosis. J Clin Exp Hepatol. 2022 Jan-Feb;12(1):237-238. doi: 10.1016/j.jceh.2021.09.021. Epub 2021 Oct 1. PMID: 35068808; PMCID: PMC8766702.
Duseja A, Singh SP, De A, Madan K, Rao PN, Shukla A, Choudhuri G, Saigal S, Shalimar, Arora A, Anand AC, Das A, Kumar A, Eapen CE, Devadas K, Shenoy KT, Panigrahi M, Wadhawan M, Rathi M, Kumar M, Choudhary NS, Saraf N, Nath P, Kar S, Alam S, Shah S, Nijhawan S, Acharya SK, Aggarwal V, Saraswat VA, Chawla YK. Indian National Association for Study of the Liver (INASL) Guidance Paper on Nomenclature, Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease (NAFLD). J Clin Exp Hepatol. 2023 Mar-Apr;13(2):273-302. doi: 10.1016/j.jceh.2022.11.014. Epub 2022 Dec 7. PMID: 36950481; PMCID: PMC10025685.
Nagral A, Sarma MS, Matthai J, Kukkle PL, Devarbhavi H, Sinha S, Alam S, Bavdekar A, Dhiman RK, Eapen CE, Goyal V, Mohan N, Kandadai RM, Sathiyasekaran M, Poddar U, Sibal A, Sankaranarayanan S, Srivastava A, Thapa BR, Wadia PM, Yachha SK, Dhawan A. Corrigendum to "Wilson's Disease: Clinical Practice Guidelines of the Indian National Association for the Study of Liver (INASL), The Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) and the Movement Disorders Society of India (MDSI)" [J Clin Exp Hepatol 9 (2019) 74-98]. J Clin Exp Hepatol. 2020 Jan-Feb;10(1):99. doi: 10.1016/j.jceh.2019.12.001. Epub 2019 Dec 10. Erratum for: J Clin Exp Hepatol. 2019 Jan-Feb;9(1):74-98. PMID: 32025169; PMCID: PMC6995886.
Verma N, Choudhury A, Singh V, Duseja A, Al-Mahtab M, Devarbhavi H, Eapen CE, Goel A, Ning Q, Duan Z, Hamid S, Jafri W, Butt AS, Shukla A, Tan SS, Kim DJ, Hu J, Sood A, Goel O, Midha V, Ghaznian H, Sahu MK, Lee GH, Treeprasertsuk S, Shah S, Lesmana LA, Lesmana RC, Prasad VGM, Sarin SK; APASL ACLF Research Consortium (AARC) for APASL ACLF Working Party. APASL-ACLF Research Consortium-Artificial Intelligence (AARC-AI) model precisely predicts outcomes in acute-on-chronic liver failure patients. Liver Int. 2023 Feb;43(2):442-451. doi: 10.1111/liv.15361. Epub 2022 Oct 11. PMID: 35797245.
Vijayalekshmi B, Choudhary A, Alexander V, Prabhu SB, Sharma A, Balasubramanian KA, Zachariah U, Eapen CE, Goel A. Reticuloendothelial activation and phenotypic alteration of peripheral monocytes with enhanced liver recruitment drive liver injury secondary to yellow phosphorus. J Gastroenterol Hepatol. 2023 Apr 29. doi: 10.1111/jgh.16198. Epub ahead of print. PMID: 37119052. Link
Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, Saraf N, Soin AS, Devarbhavi H, Kim DJ, Dhiman RK, Duseja A, Taneja S, Eapen CE, Goel A, Ning Q, Chen T, Ma K, Duan Z, Yu C, Treeprasertsuk S, Hamid SS, Butt AS, Jafri W, Shukla A, Saraswat V, Tan SS, Sood A, Midha V, Goyal O, Ghazinyan H, Arora A, Hu J, Sahu M, Rao PN, Lee GH, Lim SG, Lesmana LA, Lesmana CR, Shah S, Prasad VGM, Payawal DA, Abbas Z, Dokmeci AK, Sollano JD, Carpio G, Shresta A, Lau GK, Fazal Karim M, Shiha G, Gani R, Kalista KF, Yuen MF, Alam S, Khanna R, Sood V, Lal BB, Pamecha V, Jindal A, Rajan V, Arora V, Yokosuka O, Niriella MA, Li H, Qi X, Tanaka A, Mochida S, Chaudhuri DR, Gane E, Win KM, Chen WT, Rela M, Kapoor D, Rastogi A, Kale P, Rastogi A, Sharma CB, Bajpai M, Singh V, Premkumar M, Maharashi S, Olithselvan A, Philips CA, Srivastava A, Yachha SK, Wani ZA, Thapa BR, Saraya A, Shalimar, Kumar A, Wadhawan M, Gupta S, Madan K, Sakhuja P, Vij V, Sharma BC, Garg H, Garg V, Kalal C, Anand L, Vyas T, Mathur RP, Kumar G, Jain P, Pasupuleti SSR, Chawla YK, Chowdhury A, Alam S, Song DS, Yang JM, Yoon EL; APASL ACLF Research Consortium (AARC) for APASL ACLF working Party.. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int. 2019 Jul;13(4):353-390. doi: 10.1007/s12072-019-09946-3. Epub 2019 Jun 6. Erratum in: Hepatol Int. 2019 Nov;13(6):826-828. PMID: 31172417; PMCID: PMC6728300. Link
Ponnuvel S, Prakash A, Steve RJ, Doss GP, Goel A, Zachariah UG, Eapen CE, Rebekah G, Kannangai R, Fletcher GJ, Abraham P. Longitudinal assessment of HCV core antigen kinetics to monitor therapeutic response in the age of DAAs. PLoS One. 2023 Feb 17;18(2):e0282013. doi: 10.1371/journal.pone.0282013. PMID: 36800372; PMCID: PMC9937470.
Zachariah U, Nair SC, Goel A, Balasubramanian KA, Mackie I, Elias E, Eapen CE. Targeting raised von Willebrand factor levels and macrophage activation in severe COVID-19: Consider low volume plasma exchange and low dose steroid. Thromb Res. 2020 Aug;192:2. doi: 10.1016/j.thromres.2020.05.001. Epub 2020 May 5. PMID: 32403033; PMCID: PMC7198395.
Puri P, Anand AC, Saraswat VA, Acharya SK, Dhiman RK, Sarin SK, Singh SP, Chawla YK, Aggarwal R, Amarapurkar D, Arora A, Dixit VK, Sood A, Shah S, Duseja A, Kapoor D, Shalimar, Madan K, Pande G, Nagral A, Kar P, Koshy A, Puri AS, Eapen CE, Thareja S. Indian National Association for Study of the Liver (INASL) Guidance for Antiviral Therapy Against HCV Infection in 2015. J Clin Exp Hepatol. 2015 Sep;5(3):221-38. doi: 10.1016/j.jceh.2015.09.002. Epub 2015 Sep 21. PMID: 26628840; PMCID: PMC4632106.
Shukla A, Shreshtha A, Mukund A, Bihari C, Eapen CE, Han G, Deshmukh H, Cua IHY, Lesmana CRA, Al Meshtab M, Kage M, Chaiteeraki R, Treeprasertsuk S, Giri S, Punamiya S, Paradis V, Qi X, Sugawara Y, Abbas Z, Sarin SK. Budd-Chiari syndrome: consensus guidance of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int. 2021 Jun;15(3):531-567. doi: 10.1007/s12072-021-10189-4. Epub 2021 Jul 8. PMID: 34240318.
Vijayalekshmi B, Sharma A, Prabhu SB, Nair SC, Mammen J, Goel A, Zachariah UG, Dutta AK, Balasubramanian KA, Elias E, Eapen CE. Reticuloendothelial activation correlates with disease severity and predicts mortality in severe alcoholic hepatitis. Eur J Gastroenterol Hepatol. 2021 Dec 1;33(1S Suppl 1):e329-e334. doi: 10.1097/MEG.0000000000002056. PMID: 33470708.
Rajeeb Jaleel, Anand Sharma, Vimala Selvaraj, Rekha Aaron, Jayaprakash Muliyil, Balakrishnan Vijayalekshmi, Kunnisery Ananthsubramanian Balasubramanian, Balavendra Antonisamy, Ashish Goel, Uday George Zachariah, Chundamannil Eapen Eapen. Dynamic scoring of appetite predicts inpatient survival in patients with acute‑on‑chronic liver failure. Gastroenterol Hepatol Endosc Pract 2021;1:143-7. DOI:10.4103/ghep.ghep_8_21
Eapen CE, Balasubramanian V, Ramamoorthy G, Jayanthi V, Sathiyasekaran M, Murugan N, Palaniswamy KR, Mohan P, Premkumar K, Ramakrishna BS, Govindarajan R, Ramalingam R, Shanmugham RM, Ubaldhus J, Leelakrishnan V. Management of rodenticide poisoning: Tamil Nadu chapter of Indian Society of gastroenterology guidelines. Gastroenterol Hepatol Endosc Pract 2022;2:1-6. DOI: 10.4103/ghep.ghep_45_21
Alexander V, Rasalam JE, Kumar S, Daniel D, Nair SC, Subramani K, Chacko B, James EJ, David VG, Varughese S, Patel L, Jayalakshmi VT, Singh KA, Kumar S, Zachariah U, Goel A, Eapen CE. Transfusion-related lung complications are uncommon in non-ventilated liver failure patients undergoing low-volume plasma exchange. Indian J Gastroenterol. 2023 Aug 12. doi: 10.1007/s12664-023-01429-6. Epub ahead of print. PMID: 37572266. Link
Chandrashekaraiah Bharath Kumar, Ashish Goel, Rajeeb Jaleel, Deepu David, Uday Zachariah, Jeyamani Ramachandran, Chundamannil E. Eapen, Prevalence of Risk Factors for Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Patients With Cryptogenic Cirrhosis, Journal of Clinical and Experimental Hepatology,2021, https://doi.org/10.1016/j.jceh.2021.05.008
Santhosh E. Kumar, Ashish Goel, Uday Zachariah, Sukesh C. Nair, Vinoi G. David, Santosh Varughese, Prashanth B. Gandhi, Amit Barpha, Anand Sharma, Balakrishnan Vijayalekshmi, Kunissery A. Balasubramanian, Elwyn Elias, Chundamannil Eapen Eapen, Low Volume Plasma Exchange and Low Dose Steroid Improve Survival in Patients With Alcohol-Related Acute on Chronic Liver Failure and Severe Alcoholic Hepatitis – Preliminary Experience, Journal of Clinical and Experimental Hepatology, 2021, ISSN 0973-6883, https://doi.org/10.1016/j.jceh.2021.07.010. (https://www.sciencedirect.com/science/article/pii/S0973688321001778) Abstract: Background Alcohol-related acute on chronic liver failure (A-ACLF) patients have high short-term mortality and are poor candidates for steroid therapy. Plasma exchange (PLEX) improves survival in ACLF patients. We analyzed our experience with low volume PLEX (50% of plasma volume exchanged per session) and low dose steroids to treat A-ACLF patients. Methods We retrospectively compared the efficacy of low volume PLEX and low-dose steroids with standard medical treatment (SMT) in A-ACLF patients treated at our center between November 2017 to June 2019. The primary study outcome was one-year survival. Results Twenty-one A-ACLF patients in PLEX group [age 40 (29–56) years, median (range); MELD score 31 (29–46)] and 29 A-ACLF patients in SMT group [age 41.5 (28–63) years, MELD score 37 (21–48)] were studied. All 50 study patients had severe alcoholic hepatitis [mDF 84.7 (50–389)]. PLEX group patients had 3 (1–7) PLEX sessions with 1.5 (1.4–1.6) liters of plasma exchanged per session and oral Prednisolone 20 mg daily, tapered over 1 month. Kaplan Meier analysis showed better survival over 1 year in the PLEX group compared to the SMT group (P = 0.03). There was renal dysfunction in 10 patients in the PLEX group, which normalized in six patients after PLEX. Conclusion
Rekha Aaron, Aaron Chapla, Sumita Danda, Uday Zachariah, Chundamannil E. Eapen, Ashish Goel, Multiplex PCR-based Sequencing of ATP7B Gene in Wilson's Disease – A Preliminary Study, Journal of Clinical and Experimental Hepatology,2021, , ISSN 0973-6883, https://doi.org/10.1016/j.jceh.2021.08.001. (https://www.sciencedirect.com/science/article/pii/S0973688321001845)
Varghese J, Varghese James J, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE, Jacob M. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2020 Mar;58:126442. doi: 10.1016/j.jtemb.2019.126442. Epub 2019 Nov 28. PMID: 31835128. Link
Kumar SE, Goel A, Zachariah U, Nair SC, David VG, Varughese S, Gandhi PB, Barpha A, Sharma A, Vijayalekshmi B, Balasubramanian KA, Elias E, Eapen CE. Low Volume Plasma Exchange and Low Dose Steroid Improve Survival in Patients With Alcohol-Related Acute on Chronic Liver Failure and Severe Alcoholic Hepatitis - Preliminary Experience. J Clin Exp Hepatol. 2022 Mar-Apr;12(2):372-378. doi: 10.1016/j.jceh.2021.07.010. Epub 2021 Jul 21. PMID: 35535077; PMCID: PMC9077153.
Duseja A, De A, Taneja S, Choudhury AK, Devarbhavi H, Hu J, Hamid SS, Butt AS, Jafri SMW, Ghazinian H, Chawla YK, Dhiman RK, Duan Z, Chen Y, Tan SS, Lee GH, Lim SG, Kim DJ, Sahu M, Sollano JD, Carpio G, Mohan Prasad VG, Abbas Z, Lesmana LA, Lesmana CR, Eapen CE, Goel A, Sood A, Midha V, Goyal O, Dokmeci AK, Ning Q, Chen T, Ma K, Payawal DA, Lau GKK, Al Mahtab M, Rahman S, Alam MS, Shukla A, Shrestha A, Shah S, Kalal CR, Kumar G, Jain P, Paulson I, Sarin SK; APASL ACLF Working Party, APASL ACLF Research Consortium (AARC). Impact of metabolic risk factors on the severity and outcome of patients with alcohol-associated acute-on-chronic liver failure. Liver Int. 2021 Jan;41(1):150-157. doi: 10.1111/liv.14671. PMID: 32970356.
Nicoletti P, Devarbhavi H, Goel A, Venkatesan R, Eapen CE, Grove JI, Zafer S, Bjornsson E, Lucena MI, Andrade RJ, Pirmohamed M, Wadelius M, Larrey D, Maitland-van der Zee AH, Ibanez L, Watkins PB, Daly AK, Aithal GP. Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens. Clin Pharmacol Ther. 2021 Apr;109(4):1125-1135. doi: 10.1002/cpt.2100. Epub 2020 Dec 5. PMID: 33135175.
Devarbhavi H, Joseph T, Sunil Kumar N, Rathi C, Thomas V, Prasad Singh S, Sawant P, Goel A, Eapen CE, Rai P, Arora A, Leelakrishnan V, Gopalakrishnan G, Vardhan Reddy V, Singh R, Goswami B, Venkataraman J, Balaraju G, Patil M, Patel R, Taneja S, Koshy A, Nagaraja Rao P, Kumar Sarin S, Rathi P, Dhiman R, Duseja AK, Vargese J, Kumar Jain A, Wadhawan M, Ranjan P, Karanth D, Ganesh P, Nijhawan S, Krishna Dhali G, Adarsh CK, Jhaveri A, Nagral A, Rao P, Shalimar. The Indian Network of Drug-Induced Liver Injury: Etiology, Clinical Features, Outcome and Prognostic Markers in 1288 Patients. J Clin Exp Hepatol. 2021 May-Jun;11(3):288-298. doi: 10.1016/j.jceh.2020.11.002. Epub 2020 Nov 17. PMID: 33994711; PMCID: PMC8103312.
Abraham R, Ramakrishna B, Balekuduru A, Daniel HD, Abraham P, Eapen CE, Kurian G. Clinicopathological features and genotype distribution in patients with hepatitis C virus chronic liver disease. Indian J Gastroenterol. 2009 Mar-Apr;28(2):53-8. doi: 10.1007/s12664-009-0018-z. Epub 2009 Aug 21. PMID: 19696989.
Anand AC, Nandi B, Acharya SK, Arora A, Babu S, Batra Y, Chawla YK, Chowdhury A, Chaoudhuri A, Eapen EC, Devarbhavi H, Dhiman RK, Datta Gupta S, Duseja A, Jothimani D, Kapoor D, Kar P, Khuroo MS, Kumar A, Madan K, Mallick B, Maiwall R, Mohan N, Nagral A, Nath P, Panigrahi SC, Pawar A, Philips CA, Prahraj D, Puri P, Rastogi A, Saraswat VA, Saigal S, Shalimar, Shukla A, Singh SP, Verghese T, Wadhawan M; INASL Task-Force on Acute Liver Failure. Erratum to 'Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure' [J Clin Exp Hepatol 10 (2020) 477-517]. J Clin Exp Hepatol. 2022 Mar-Apr;12(2):729-730. doi: 10.1016/j.jceh.2022.01.003. Epub 2022 Jan 11. Erratum for: J Clin Exp Hepatol. 2020 Sep-Oct;10(5):477-517. PMID: 35535113; PMCID: PMC9077233.
Steve RJ, Prakash A, Ponnuvel S, Dickson CJ, Nandan K, Singh B, Sam GA, Goel A, Zachariah UG, Eapen CE, Kannangai R, Abraham P, Fletcher GJ. Versatile performance edges of HBsAg Next assay in diagnosis and therapeutic monitoring of HBV infection. J Clin Virol. 2023 Jan 11;160:105378. doi: 10.1016/j.jcv.2023.105378. Epub ahead of print. PMID: 36641983.
Sharma A, Eapen CE. Pelvic congestion needs attention in infertile women with Budd-Chiari syndrome. Indian J Gastroenterol. 2023 Feb 10. doi: 10.1007/s12664-023-01341-z. Epub ahead of print. PMID: 36763250.
Sharma A, Goel A, Moses V, Keshava SN, Zachariah UG, Elias E, Eapen CE. Anticoagulating Budd-Chiari syndrome patients presenting with variceal bleed: A retrospective study. J Gastroenterol Hepatol. 2020 Aug;35(8):1397-1403. doi: 10.1111/jgh.14971. Epub 2020 Jan 16. PMID: 31900982.
Aaron R, Chapla A, Danda S, Zachariah U, Eapen CE, Goel A. Multiplex PCR-based Sequencing of ATP7B Gene in Wilson's Disease - A Preliminary Study. J Clin Exp Hepatol. 2022 Mar-Apr;12(2):711-713. doi: 10.1016/j.jceh.2021.08.001. Epub 2021 Aug 6. PMID: 35535059; PMCID: PMC9077194.
Thomas L, Chandran J, Goel A, Jacob E, Chacko B, Subramani K, Agarwal I, Varughese S, David VG, Daniel D, Mammen J, Balakrishnan V, Balasubramanian KA, Lionel AP, Adhikari DD, Abhilash KPP, Elias E, Eapen CE, Zachariah U. Improving Transplant-free Survival With Low-volume Plasma Exchange to Treat Children With Rodenticide Induced Hepatotoxicity. J Clin Exp Hepatol. 2023 Mar-Apr;13(2):252-258. doi: 10.1016/j.jceh.2022.10.013. Epub 2022 Nov 12. PMID: 36950489; PMCID: PMC10025587.
Aaron R, Premkumar K, Chapla A, Vijayalekshmi B, Zachariah U, Elias E, Kodiatte TA, Daniel D, Jude J, Balasubramanian KA, Nair SC, Thomas N, Ramakrishna B, Eapen CE, Goel A. Focused panel sequencing points to genetic predisposition in non-cirrhotic intrahepatic portal hypertension patients in India. Indian J Gastroenterol. 2023 Oct 5. doi: 10.1007/s12664-023-01454-5. Epub ahead of print. PMID: 37796423.
Sardar D, Mathews N, Mammen J, Nair SC, Jacob S, Patel L, Thomas A, Jhanwar S, Sharma A, Sen M, Vijayalekshmi B, Balasubramanian KA, Subramani K, Thomas L, Abhilash KPP, Zachariah U, Elias E, Goel A, Eapen CE. Rodenticidal hepatotoxicity: Raised plasma Von Willebrand factor levels predict in-hospital survival and preliminary report of the outcome of Von Willebrand factor reducing management protocol. Indian J Gastroenterol. 2019 Dec;38(6):527-533. doi: 10.1007/s12664-019-00989-w. Epub 2020 Feb 19. PMID: 32077040.
Loganathan G, Eapen CE, Chandy RG, Jasper P, Mathai M, Seshadri L, Ramakrishna B, Jana AK, John G, Chandy GM. Acute fatty liver of pregnancy: a report of two cases. Natl Med J India. 2002 Nov-Dec;15(6):336-8. PMID: 12540067. Link
Bera C, Michael JS, Burad D, Shirly SB, Gibikote S, Ramakrishna B, Goel A, Eapen CE. Tissue Xpert™ MTB/Rif assay is of limited use in diagnosing peritoneal tuberculosis in patients with exudative ascites. Indian J Gastroenterol. 2015 Sep;34(5):395-8. doi: 10.1007/s12664-015-0599-7. Epub 2015 Nov 4. PMID: 26531065.
Goel A, Zachariah U, Daniel D, Eapen CE. Growing Evidence for Survival Benefit with Plasma Exchange to Treat Liver Failure. J Clin Exp Hepatol. 2023 Nov-Dec;13(6):1061-1073. doi: 10.1016/j.jceh.2023.06.002. Epub 2023 Jun 14. PMID: 37975044; PMCID: PMC10643514.
Singh KA, Kumar SE, Zachariah UG, Daniel D, David V, Subramani K, Pichamuthu K, Jacob E, Kodiatte TA, Eapen CE, Goel A. Single-Centre Experience With Low-Volume Plasma Exchange and Low-Dose Steroid to Treat Patients With Idiosyncratic Drug-Induced Acute Liver Failure. J Clin Exp Hepatol. 2024 Mar-Apr;14(2):101303. doi: 10.1016/j.jceh.2023.11.003. Epub 2023 Nov 7. PMID: 38076447; PMCID: PMC10698001.
Singh V, De A, Mehtani R, Angeli P, Maiwall R, Satapathy S, Singal AK, Saraya A, Sharma BC, Eapen CE, Rao PN, Shukla A, Shalimar, Choudhary NS, Alcantara-Payawal D, Arora V, Aithal G, Kulkarni A, Roy A, Shrestha A, Mamun Al Mahtab, Niriella MA, Siam TS, Zhang CQ, Huei LG, Yu ML, Roberts SK, Peng CY, Chen T, George J, Wong V, Yilmaz Y, Treeprasertsuk S, Kurniawan J, Kim SU, Younossi ZM, Sarin SK. Asia-Pacific association for study of liver guidelines on management of ascites in liver disease. Hepatol Int. 2023 Aug;17(4):792-826. doi: 10.1007/s12072-023-10536-7. Epub 2023 May 26. PMID: 37237088.
Eapen CE. Recurrence of Helicobacter pylori infection after eradication. Indian J Gastroenterol. 2000 Aug;19 Suppl 1:S25-7; discussion S27-8. PMID: 11060973. Link
Bera C, Thangaraj K, Pati PK, Ramachandran J, Balasubramanian KA, Ramachandran A, Zachariah U, Sajith KG, Goel A, Eapen CE. Raised plasma levels of H2S and nitrate predict intrapulmonary vascular dilations: A preliminary report in patients with cryptogenic cirrhosis. Indian J Gastroenterol. 2018 May;37(3):209-214. doi: 10.1007/s12664-018-0862-9. Epub 2018 Jul 9. PMID: 29984390.
Eapen CE, Kumar S, Fleming JJ, Ramakrishna B, Abraham L, Ramachandran J. Copper and liver disease. Gut. 2012 Jan;61(1):63. doi: 10.1136/gutjnl-2011-301743. Erratum in: Gut. 2012 May;61(5):773. Kumar, Suresh [added]; Fleming, J J [added]; Ramakrishna, B [added]; Abraham, L [added]; Ramachandran, J [added]. PMID: 22139599.
Singh KA, Anandan S, Sharma A, Kumar SE, Solaimalai D, Veeraraghavan B, Goel A, Eapen CE, Zachariah UG. High Mortality With Non-O1/Non-O139 Vibrio cholera Bacteraemia in Patients With Cirrhosis. J Clin Exp Hepatol. 2024 May-Jun;14(3):101346. doi: 10.1016/j.jceh.2024.101346. Epub 2024 Jan 17. PMID: 38371607; PMCID: PMC10869911.
Zachariah U, Vijayalekshmi B, Matthai SM, Goel A, Eapen CE. Extra-corporeal non-liver transplant therapies for acute liver failure: Focus on plasma exchange and continuous renal replacement therapy. Indian J Gastroenterol. 2024 Mar 26. doi: 10.1007/s12664-024-01558-6. Epub ahead of print. PMID: 38530631.
